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Abstract
Lung adenocarcinoma is the leading cause of cancer related deaths worldwide. The causes for adenocarcinoma include smoking, air pollution, family history, occupational exposure, silica, asbestos, diesel fumes, and heavy metals. Smoking increases lung cancer risk by 5- to 10 fold with a clear dose–response relationship and environmental tobacco smoke among non-smokers increases lung cancer risk by about 20 %.[1] Lung cancers can be classified into two types based on histology as small cell carcinoma and non-small cell carcinoma. Adenocarcinoma falls under non-small cell carcinoma. Non-small cell carcinoma is further classified into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Polyserositis is a condition where there is an inflammation of serous membranes with effusion. Most common sites are pleura and pericardium presenting with symptoms like chest pain, and shortness of breath.[2] The causes include idiopathic, infectious disease like tuberculosis, autoimmune conditions like SLE, and neoplasm. Neoplasm is the most common cause (nearly one-third of cases). Autoimmune disease like Adult-onset Still's disease presents with cardiac and pulmonary involvement pleural effusion, pericarditis and serositis.[3] A possible manifestation of systemic lupus erythematosus is extensive serous involvement like pericardial effusion and pleural effusion.[4] In this case report, we discuss the presentation of adenocarcinoma and pericardial effusion with liver metastasis in a 74-year-old female.
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References
- Shwartz AG, Cote ML. Epidemiology of lung cancer. https://link.springer.com/chapter/10.1007/978-3-319-24223-1_2
- Losada I, González‐Moreno J, Roda N, et al. Polyserositis: a diagnostic challenge. Intern Med J 2018;48(8):982-7.
- Neto NS, Waldrich L, de Carvalho JF, et al. Adult-onset Still's disease with pulmonary and cardiac involvement and response to intravenous immunoglobulin. Acta Reumatol Port 2009;34(4):628-32.
- López JG, Florian JD. Polyserositis as a probable early manifestation of systemic lupus erythematosus. American Journal of Medical Case Reports 2022;10(7):173-7.
- Vemireddy LP, Jain N, Aqeel A, et al. Lung adenocarcinoma presenting as malignant pericardial effusion/tamponade. Cureus 2021;13(3):e13762.
- Gadewad N, Deokar K, Ghorpade S. Clinical profile of patients presenting with malignant pleural effusion to a tertiary health care centre. J Assoc Physicians India 2017;65(8):28-31.
- Amicizia D, Piazza MF, Marchini F, et al. Systematic review of lung cancer screening: advancements and strategies for implementation. Healthcare 2023;11(14):2085.
References
Shwartz AG, Cote ML. Epidemiology of lung cancer. https://link.springer.com/chapter/10.1007/978-3-319-24223-1_2
Losada I, González‐Moreno J, Roda N, et al. Polyserositis: a diagnostic challenge. Intern Med J 2018;48(8):982-7.
Neto NS, Waldrich L, de Carvalho JF, et al. Adult-onset Still's disease with pulmonary and cardiac involvement and response to intravenous immunoglobulin. Acta Reumatol Port 2009;34(4):628-32.
López JG, Florian JD. Polyserositis as a probable early manifestation of systemic lupus erythematosus. American Journal of Medical Case Reports 2022;10(7):173-7.
Vemireddy LP, Jain N, Aqeel A, et al. Lung adenocarcinoma presenting as malignant pericardial effusion/tamponade. Cureus 2021;13(3):e13762.
Gadewad N, Deokar K, Ghorpade S. Clinical profile of patients presenting with malignant pleural effusion to a tertiary health care centre. J Assoc Physicians India 2017;65(8):28-31.
Amicizia D, Piazza MF, Marchini F, et al. Systematic review of lung cancer screening: advancements and strategies for implementation. Healthcare 2023;11(14):2085.