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Abstract
Metaplastic carcinoma is a diverse subgroup of invasive breast cancer (IBC) characterised by differentiation of the neoplastic epithelium into squamous cells and/or mesenchymal-looking components, such as but not limited to spindle, chondroid and osseous cells. [1] The clinical characteristics are comparable to those of ER-negative IBC of no special type (NST), although they are more likely to present at an advanced stage. The aetiology is complicated and doesn't seem to be different from IBC-NST (especially the triple-negative subtype). [2] They account for 0.2-1 % of all IBCs. This variation in prevalence stems from the different definitions of metaplastic carcinoma used by different authors.
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References
- Hasdemir O, Tokgöz S, Köybaşioğlu F, et al. Clinicopathological features of metaplastic breast carcinoma. Adv Clin Exp Med 2018;27(4):509-13.
- Jagtap SV, Bhosale SJ, Kshirsagar AY, et al. Matrix-producing metaplastic breast carcinoma - a rare malignancy. Am J Case Rep 2013;14:213-5.
- Cha N, Wang S, Lv M, et al. breast metaplastic squamous cell carcinoma diagnosed with fine needle and core biopsy: a case study. Am J Case Rep 2018;19:203-6.
- WHO classification of tumours editorial board: breast tumours. 5th edn. Lyon, France: International Agency for Research on Cancer 2022.
- Toumi Z, Bullen C, Tang ACS, et al. Metaplastic breast carcinoma: a case report and systematic review of the literature. Pathol Int 2011;61(10):582-8.
- Bigotti G, Di Filippo S, Di Filippo F, et al. An unusual case of metaplastic breast carcinoma following neoadjuvant chemotherapy. Pathol Int 2012;62(1):72-4.
References
Hasdemir O, Tokgöz S, Köybaşioğlu F, et al. Clinicopathological features of metaplastic breast carcinoma. Adv Clin Exp Med 2018;27(4):509-13.
Jagtap SV, Bhosale SJ, Kshirsagar AY, et al. Matrix-producing metaplastic breast carcinoma - a rare malignancy. Am J Case Rep 2013;14:213-5.
Cha N, Wang S, Lv M, et al. breast metaplastic squamous cell carcinoma diagnosed with fine needle and core biopsy: a case study. Am J Case Rep 2018;19:203-6.
WHO classification of tumours editorial board: breast tumours. 5th edn. Lyon, France: International Agency for Research on Cancer 2022.
Toumi Z, Bullen C, Tang ACS, et al. Metaplastic breast carcinoma: a case report and systematic review of the literature. Pathol Int 2011;61(10):582-8.
Bigotti G, Di Filippo S, Di Filippo F, et al. An unusual case of metaplastic breast carcinoma following neoadjuvant chemotherapy. Pathol Int 2012;62(1):72-4.