Main Article Content
Abstract
BACKGROUND
This study was conducted to evaluate the serum lipid profile in different grades of POAG patients and describe the demographic profile of POAG patients.
METHODS
This was a hospital based observational study comprising of 80 eyes of 40 POAG patients who visited OPD in the Department of Ophthalmology, Adichunchanagiri Institute of Medical Sciences, B.G. Nagara, Mandya District, over a period of 18 months from March 2021 to August 2022 after obtaining clearance from the institutional ethics committee and written informed consent from the study participants.
RESULTS
Of the 40 study participants, males constituted 62.5% (n=25) and females 32.5% (n=13) in the age group of 70 to 80 years 30% of patients had normal vision; the rest had visual impairments ranging from mild to total blindness. High cholesterol levels were present in 27.5% (n=11), high triglyceride in 42.5% (n=17), low HDL levels were present in 40% (n=16), High LDL levels were observed among 30% (n=12) of participants and high VLDL in 57.5% (n=23). The differences in the distribution of different grades of POAG with respect to different levels of total cholesterol and LDL were not significant, with p-values of 0.202 and 0.123 respectively. However, it was statistically significant for low HDL, high triglycerides and high VLDL with p value of 0.004, 0.05 and 0.017 respectively.
CONCLUSIONS
In conclusion, this observational study discovered that there is a significant relationship between dyslipidaemia to POAG. Low levels of HDL, high triglycerides, and high VLDL have a significant relationship (p<0.05) to the occurrence of POAG. This lends credence to the idea that abnormal lipid levels increase the likelihood of developing glaucoma.
Keywords
Article Details

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References
- Stamper R, Lieberman M, Drake M. Becker-Shaffer's diagnosis and therapy of the glaucomas. 8th edn. St. Louis, Mo: Mosby Elsevier 2009.
- Tham Y, Li X, Wong T, et al. Global Prevalence of glaucoma and projections of glaucoma burden through 2040. Ophthalmology 2014;121(11):2081-90.
- George R, Ve R, Vijaya L. Glaucoma in India: estimated burden of disease. Journal of Glaucoma 2010;19(6):391-97.
- Allingham R. Shields' textbook of glaucoma. 5th edn. USA: Lippincott Williams & Wilkins 2005.
- Sihota R, Tandon R. Parson’s diseases of the eye. 23rd edn. New Delhi: Elsevier 2019.
- Foster PJ, Buhrmann R, Quigley HA, et al. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol 2002;86(2):238-42.
- National Cholesterol Education Program. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adult (Adult Treatment Panel 3). JAMA 2001;285(19):2486 -97.
- WHO International Statistical Classification of Diseases and Related Health Problems. 10th revision. Chap- VII H54 Blindness and low vision. 2016
- Dube M. Correlation between serum lipids and primary open angle glaucoma: a clinical study. Delhi J Ophthalmol 2019;29(4):58-60.
- Dandona L, Dandona R, Srinivas M, et al. Open angle glaucoma in an urban population in southern India: the Andhra Pradesh Eye Disease Study. Ophthalmology 2000;107:1702-9.
- World Health Organization. World Report on Vision. 2019. Available from: https://wwwwhoint/publications-detail/world-report-on-vision
- Zhang Y, Jin G, Fan M, et al. Time trends and heterogeneity in the disease burden of glaucoma, 1990-2017: A global analysis. J Glob Health 2019;9(2):020436.
- Jin S, Trope GE, Buys YM, et al. Reduced social participation among seniors with self-reported visual impairment and glaucoma. PLoS One 2019;14:e0218540.
- Posch-Pertl L, Michelitsch M, Wagner G, et al. Cholesterol and glaucoma: a systematic review and meta-analysis. Acta Ophthalmol 2022;100(2):148-58.
- Modrzejewska M, Grzesiak W, Zaborski D, et al. The role of lipid dysregulation and vascular risk factors in glaucomatous retrobulbar circulation. Bosn J Basic Med Sci 2015;15: 50-6.
- Pertl L, Mossböck G, Wedrich A, et al. Triglycerides and open angle glaucoma - a meta-analysis with meta-regression. Sci Rep 2017;7(1):7829.
- Chapman MJ, Ginsberg HN, Amarenco P, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 2011;32(11):1345-61.
- Quispe R, Manalac RJ, Faridi KF, et al. Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: the Very Large Database of Lipids-4 (VLDL-4) study. Atherosclerosis 2015;242(1):243-50.
- Davari M, Kazemi T, Rezai A. A survey of the relationship between serum cholesterol and triglyceride to glaucoma: a case control study. Journal of Basic & Applied Sciences 2014;10:39-43.
- Chisholm IA, Stead S. Plasma lipid patterns in patients with suspected glaucoma. Can J Ophthalmol 1988;23(4):164-7.
- Kovačević S, Jurin A, Didović-Torbarina A. Dislipidmija u bolesnikas a Primarnim zlaukomomotvorenogugla. Abstracts of the 7th Congress of the Croatian Ophthalmol. Society with International Participation. Ophthalmol Croatica 2007;16:51.
- Pavljašević S, Ašćerić M. Primary open-angle glaucoma and serum lipids. Bosnian Journal of Basic Medical Sciences 2009;9(1):85-8.
- Saikia M, Phukan JK, Gogoi B, et al. A study of serum fasting lipid profile and serum total protein and fractions in normotensive non-diabetic glaucoma patients. Global J Res Anal 2016;5(6).
- Kashiwagi E, Masuno K, Fujisawa K, et al. Glaucoma in a New Zealand White Rabbit Fed High-cholesterol Diet. J Toxicol Pathol 2012;25(1):51-3.
- Wierzbowska J, Figurska M, Stankiewicz A, et al. Risk factors in age related macular degeneration and glaucoma - own observations. Klin Oczna 2008;110(4):370-4.
- Egorow W, Bachaldin IL, Sorokin EF. Characteristics of morphological and functional state of erytrocytes in patients with primary open angle glaucoma with normalized intraocular pressure. Vestn Ophthalmol 2001;117(2):5-8.
- Newman-Casey PA, Talwar N, Nan B, et al. The relationship between components of metabolic syndrome and open-angle glaucoma. Ophthalmology 2011;118(7): 1318-26.
- Stewart WC, Sine C, Sutherland S, et al. Total cholesterol and high-density lipoprotein levels as risk factors for increased intraocular pressure. Am J Ophthalmol 1996;122(4): 575-7.
- Wang S, Xu L, Jonas J, et al. Dyslipidemia and eye diseases in the adult Chinese population: the Beijing Eye Study. PLoS One 2012;7(3):26871.
- Jonas JB, Aung T, Bourne RR, et al. Glaucoma. Lancet 2017;390(10108):2183-93.
- Roddy GW. Metabolic syndrome is associated with ocular hypertension and glaucoma. J Glaucoma 2020;29(9):726-31.
- Xu X, Gao W, Cheng S, et al. Anti‐inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury. J Neuroinflammation 2017;14(1):167.
- McGwin G, McNeal S, Owsley C, et al. Statins and other cholesterol‐lowering medications and the presence of glaucoma. Arch Ophthalmol 2004;122(6):822-6.
References
Stamper R, Lieberman M, Drake M. Becker-Shaffer's diagnosis and therapy of the glaucomas. 8th edn. St. Louis, Mo: Mosby Elsevier 2009.
Tham Y, Li X, Wong T, et al. Global Prevalence of glaucoma and projections of glaucoma burden through 2040. Ophthalmology 2014;121(11):2081-90.
George R, Ve R, Vijaya L. Glaucoma in India: estimated burden of disease. Journal of Glaucoma 2010;19(6):391-97.
Allingham R. Shields' textbook of glaucoma. 5th edn. USA: Lippincott Williams & Wilkins 2005.
Sihota R, Tandon R. Parson’s diseases of the eye. 23rd edn. New Delhi: Elsevier 2019.
Foster PJ, Buhrmann R, Quigley HA, et al. The definition and classification of glaucoma in prevalence surveys. Br J Ophthalmol 2002;86(2):238-42.
National Cholesterol Education Program. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adult (Adult Treatment Panel 3). JAMA 2001;285(19):2486 -97.
WHO International Statistical Classification of Diseases and Related Health Problems. 10th revision. Chap- VII H54 Blindness and low vision. 2016
Dube M. Correlation between serum lipids and primary open angle glaucoma: a clinical study. Delhi J Ophthalmol 2019;29(4):58-60.
Dandona L, Dandona R, Srinivas M, et al. Open angle glaucoma in an urban population in southern India: the Andhra Pradesh Eye Disease Study. Ophthalmology 2000;107:1702-9.
World Health Organization. World Report on Vision. 2019. Available from: https://wwwwhoint/publications-detail/world-report-on-vision
Zhang Y, Jin G, Fan M, et al. Time trends and heterogeneity in the disease burden of glaucoma, 1990-2017: A global analysis. J Glob Health 2019;9(2):020436.
Jin S, Trope GE, Buys YM, et al. Reduced social participation among seniors with self-reported visual impairment and glaucoma. PLoS One 2019;14:e0218540.
Posch-Pertl L, Michelitsch M, Wagner G, et al. Cholesterol and glaucoma: a systematic review and meta-analysis. Acta Ophthalmol 2022;100(2):148-58.
Modrzejewska M, Grzesiak W, Zaborski D, et al. The role of lipid dysregulation and vascular risk factors in glaucomatous retrobulbar circulation. Bosn J Basic Med Sci 2015;15: 50-6.
Pertl L, Mossböck G, Wedrich A, et al. Triglycerides and open angle glaucoma - a meta-analysis with meta-regression. Sci Rep 2017;7(1):7829.
Chapman MJ, Ginsberg HN, Amarenco P, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J 2011;32(11):1345-61.
Quispe R, Manalac RJ, Faridi KF, et al. Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: the Very Large Database of Lipids-4 (VLDL-4) study. Atherosclerosis 2015;242(1):243-50.
Davari M, Kazemi T, Rezai A. A survey of the relationship between serum cholesterol and triglyceride to glaucoma: a case control study. Journal of Basic & Applied Sciences 2014;10:39-43.
Chisholm IA, Stead S. Plasma lipid patterns in patients with suspected glaucoma. Can J Ophthalmol 1988;23(4):164-7.
Kovačević S, Jurin A, Didović-Torbarina A. Dislipidmija u bolesnikas a Primarnim zlaukomomotvorenogugla. Abstracts of the 7th Congress of the Croatian Ophthalmol. Society with International Participation. Ophthalmol Croatica 2007;16:51.
Pavljašević S, Ašćerić M. Primary open-angle glaucoma and serum lipids. Bosnian Journal of Basic Medical Sciences 2009;9(1):85-8.
Saikia M, Phukan JK, Gogoi B, et al. A study of serum fasting lipid profile and serum total protein and fractions in normotensive non-diabetic glaucoma patients. Global J Res Anal 2016;5(6).
Kashiwagi E, Masuno K, Fujisawa K, et al. Glaucoma in a New Zealand White Rabbit Fed High-cholesterol Diet. J Toxicol Pathol 2012;25(1):51-3.
Wierzbowska J, Figurska M, Stankiewicz A, et al. Risk factors in age related macular degeneration and glaucoma - own observations. Klin Oczna 2008;110(4):370-4.
Egorow W, Bachaldin IL, Sorokin EF. Characteristics of morphological and functional state of erytrocytes in patients with primary open angle glaucoma with normalized intraocular pressure. Vestn Ophthalmol 2001;117(2):5-8.
Newman-Casey PA, Talwar N, Nan B, et al. The relationship between components of metabolic syndrome and open-angle glaucoma. Ophthalmology 2011;118(7): 1318-26.
Stewart WC, Sine C, Sutherland S, et al. Total cholesterol and high-density lipoprotein levels as risk factors for increased intraocular pressure. Am J Ophthalmol 1996;122(4): 575-7.
Wang S, Xu L, Jonas J, et al. Dyslipidemia and eye diseases in the adult Chinese population: the Beijing Eye Study. PLoS One 2012;7(3):26871.
Jonas JB, Aung T, Bourne RR, et al. Glaucoma. Lancet 2017;390(10108):2183-93.
Roddy GW. Metabolic syndrome is associated with ocular hypertension and glaucoma. J Glaucoma 2020;29(9):726-31.
Xu X, Gao W, Cheng S, et al. Anti‐inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury. J Neuroinflammation 2017;14(1):167.
McGwin G, McNeal S, Owsley C, et al. Statins and other cholesterol‐lowering medications and the presence of glaucoma. Arch Ophthalmol 2004;122(6):822-6.