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Abstract

BACKGROUND


In pregnant women, thyroid disorders are common endocrine problems and due to non-specific symptoms and hyper-metabolic state of pregnancy they are often neglected. To know the prevalence of thyroid disorders in pregnant women and their maternal and foetal outcome was the purpose of this study.


METHODS


This was an observational study which was conducted from 15th November 2021 to 15th May 2022 in the Department of Obstetrics and Gynaecology, Srinivas Medical College, Mukka, (Mangalore). Registration of one fifty pregnant women attending antenatal clinic in first trimester was done. Detailed history and examination was done. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) level evaluation was done apart from routine antenatal investigations.


RESULTS


Among 150 pregnant women, the prevalence of thyroid disorders is 14 (9.31 %). Subclinical hypothyroidism 9 (6 %) was the most common thyroid disorder observed. Maternal anaemia and eclampsia was most common complication 3 each (33.33 %). 1 (11 %) was antepartum haemorrhage. Thyroid disorder occurred during the 2nd trimester 58.33 %; 25 % and 16.66 % in 1st and 3rd trimester. Most commonly observed foetal birth weight in this study were between 2 - 2.5 kgs 7 (77.77 %). Most common foetal complication observed were foetal growth restriction (five) with spontaneous abortion and intra uterine foetal demise (IUFD) (one each) was noted. Out of all thyroid disorders associated with pregnancy, subclinical hypothyroidism is the most frequently noted. Patients with subclinical hypothyroidism remain asymptomatic when not treated, but had bad obstetric and neonatal outcome, although less severe than overt hypothyroidism cases.


CONCLUSIONS


Timely screening of pregnant women is required during pregnancy for the prevention of pregnancy which helps in the early diagnosis and management of complications related to maternal and foetus due to thyroid disorders.

Keywords

Pregnancy Profile, TSH, FT3, FT4, Maternal and Foetal Outcome.

Article Details

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite
Vasani Asha Kuvarji, Tahseen Fathima, Susham S Shetty, Chandaa Vinodkumar Jakkannavar, Sangeetha K, Radha Nair, Nisarg Sutaria, & Pramukh Hegde. (2023). Thyroid Disorders in Pregnancy and Their Maternal and Foetal Outcome in Tertiary Care Centre. Journal of Evolution of Medical and Dental Sciences, 12(1), 15–18. https://doi.org/10.14260/jemds.v12i1.321
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References

  1. Zhou M, Wang M, Li J, et al. Effects of thyroid diseases on pregnancy outcomes. Exp Ther Med 2019;18(3):1807-15.
  2. Pahwa S, Mangat S. Prevalence of thyroid disorders in pregnancy. Int J Reprod Contracept Obstet Gynecol 2018;7(9):3493-6.
  3. Mannisto T, Vaarasmaki M, Pouta A, et al. Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life. J Clin Endocrinol Metab 2010;95(3):1084-94.
  4. Saki F, Dabbaghmanesh MH, Ghaemi SZ, et al. Thyroid function in pregnancy and its influences on maternal and fetal outcomes. Int J Endocrinol Metab 2014;12:e19378.
  5. Korde VR, Barse SP, Barla JS. Prevalence of thyroid dysfunctions in pregnant women: a prospective study in a tertiary care hospital in Maharashtra, India. Int J Reprod Contracept Obstet Gynecol 2018;7(8):3211-5.
  6. Joshi D, Dewan R, Bharti R, et al. Feto-maternal outcome using new screening criteria of serum TSH for diagnosing hypothyroidism in pregnancy. J Clin Diagn Res 2015;9(4):QC01-3.
  7. Dong AC, Stagnaro-Green A. Differences in diagnostic criteria mask the true prevalence of thyroid disease in pregnancy: a systematic review and meta-analysis. Thyroid 2019;29(2):278-89.
  8. Reid SM, Middleton P, Cossich MC, et al. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database Sys Rev 2010;7(7):CD007752.
  9. Khakurel G, Karki C, Chalise S. Prevalence of thyroid disorder in pregnant women visiting a tertiary care teaching hospital: a descriptive cross-sectional study. J Nepal Med Assoc 2021;59(233):51-4.
  10. Casey BM, Dashe JS, Wells CE, et al. Subclinical hypothyroidism and pregnancy outcomes. Obstet Gynecol 2005;105(2):239-45.
  11. Lazarus JH. Thyroid functions in pregnancy. Br Med Bull 2011;97(1):137-48.
  12. Sahu MT, Das V, Mittal S, et al. Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome. Arch Gynecol Obstet 2010;281(2):215-20.
  13. Stagnaro-Green A, Pearce E. Thyroid disorders in pregnancy. Nat Rev Endocrinol 2012;8(11):650-8.
  14. Abalovich M, Amino N, Barbour LA, et al. Management of thyroid dysfunction during pregnancy and postpartum: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2007;92(8 Suppl):S1-47.